High Purity Trehalose CAS 99-20-7 Dietary Supplement Probiotic Stabilizer

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Product Description

Basic Info.

Model NO. 99-20-7
EINECS 202-739-6
Type Trehalose
Nutritional Value Nutritional
Effect Sweetener
Resource Chemosynthesis
MOQ 25kg
Lead Time 7 Days
Transport Package 25kg
Specification 25kg
Origin China
Production Capacity 4000t/Year

Product Description

Lock in the CFU: High Purity Trehalose for Premium Probiotic Supplements

CAS 99-20-7 | Maximum CFU Retention | Tableting Stress Protection | Ambient Shelf-Life Extender

Stop formulation failures caused by rapid probiotic die-off. Our High Purity Trehalose (CAS 99-20-7) is an advanced biological stabilizer engineered specifically for the dietary supplement industry. Operating as a superior excipient and protective matrix, it shields live cultures from mechanical stress during tableting and prevents moisture-induced degradation, ensuring your probiotic capsules and powders deliver their promised CFU count right up to the expiration date—without the need for cold-chain storage.

Technical Specifications

Product Name: Trehalose Anhydrous / Crystalline

CAS No.: 99-20-7 | Grade: Pharmaceutical / Dietary Supplement Grade

Function: Bio-Stabilizer, Premium Excipient, Lyoprotectant

Parameter Supplement Grade Specification R&D Formulation Benefit
Assay (Purity) ≥ 99.0% Ensures consistent biological stability and predictable dosing.
Moisture Content ≤ 1.5% Extremely low water activity (Aw); crucial for dormant bacteria.
Appearance White Crystalline Powder Excellent flowability for high-speed capsule filling machines.
Heavy Metals (Pb) ≤ 5 ppm Strictly complies with FDA/EFSA limits for dietary supplements.
Microbial Limit ≤ 100 cfu/g Eliminates the risk of introducing competing pathogens.
Solubility Instant Water Solubility Perfect for effervescent tablets and stick-pack powder blends.

Core Advantages (The Supplement Formulation Edge)

  • Mechanical Stress Shielding: During the production of chewable probiotic tablets, immense pressure creates heat and physical shear that kills bacteria. Trehalose absorbs this mechanical shock, maintaining the structural integrity of the cell walls.
  • Ambient Temperature Stability: Featuring an exceptionally high glass transition temperature (Tg), Trehalose locks the probiotic cells in a protective stasis, drastically reducing the CFU drop-off rate when products are stored on supermarket shelves at room temperature.
  • Low Hygroscopicity: Unlike maltodextrin, which rapidly absorbs moisture from the air and prematurely "wakes up" (and kills) the bacteria, Trehalose remains stable in high-humidity environments, preventing capsule softening or powder caking.
  • Gastric Survival Enhancement: It acts as a protective buffer against stomach acid, increasing the percentage of live cultures that successfully reach the intestines.

Mechanism of Action - The Stasis Matrix

  • The Vitrification Effect: When blended with freeze-dried probiotic powders, Trehalose forms a continuous, non-reactive "glassy" matrix. This immobilizes the bacterial proteins and cell membranes, completely halting the biological degradation process.
  • Protein Hydration Replacement: It physically replaces the water molecules around the bacterial cell, tricking the cell into remaining stable even in a totally desiccated (dry) powder state.

Application & Dosage Guide

Optimized for solid-dose and powder dietary supplements:

  • Probiotic Capsules (HPMC/Gelatin): Used as a premium filler/excipient (replacing 50-100% of microcrystalline cellulose or maltodextrin) to maximize CFU survival.
  • Chewable Probiotic Tablets: 10.0% - 30.0% of the total tablet weight. (Provides excellent compressibility and a mild, clean sweetness without risking tooth decay).
  • Synbiotic Powder Stick-Packs: Blended seamlessly with prebiotics (Inulin/FOS) and probiotic strains to ensure rapid, clear dissolution when mixed with water.
  • Gummy Supplements: Prevents moisture migration and protects heat-sensitive strains during the cooling phase of gummy manufacturing.

Quality, Compliance & Clean Label

  • Regulatory Status: GRAS (Generally Recognized As Safe). Fully compliant for use in Dietary Supplements and Nutraceuticals globally.
  • Certifications: Produced under strict ISO 22000 and HACCP guidelines. 100% Halal and Kosher certified.
  • Clean Label Advantage: Non-GMO, Vegan, Gluten-Free, and Allergen-Free. It appeals directly to health-conscious consumers reading the ingredient panel.

Packaging & Global Logistics

  • Standard Packing: 25kg multi-layer Kraft paper bags with an inner moisture-barrier PE liner to guarantee absolute dryness during transit.
  • Optimized Loading Capacity (20' FCL):
    • Floor Loaded: 20 MT (800 Bags) - Maximizes container payload.
    • Palletized: 18 MT (720 Bags / 20 Pallets) - Strongly recommended for pharmaceutical and supplement manufacturers requiring strictly hygienic unloading processes.
  • Storage: 24 months shelf life. Store in a cool, dry environment away from strong odors.

The Nutraceutical Consolidation Hub (Mixed FCL)

Streamline Your Dietary Supplement Supply Chain.

Contract manufacturers need a reliable, consolidated source for active ingredients and premium excipients. Leverage our Mixed FCL Service to combine Trehalose with our comprehensive nutraceutical portfolio:

  • Sports Nutrition & Energy: Creatine Monohydrate, Taurine.
  • Immune Support: Ascorbic Acid (Vitamin C), Sodium Ascorbate.
  • Flavor & Sweetness Systems: Sucralose, Stevia, and high-concentration natural flavor powders (Orange/Chocolate) to mask the taste of raw minerals and vitamins in your supplement blends.

Strategic FAQ for Supplement R&D

Q1 Can we completely replace Maltodextrin with Trehalose in our probiotic blends?
Yes, and it is highly recommended for premium product lines. While Maltodextrin is cheaper, it offers zero biological protection and is highly hygroscopic. Upgrading to Trehalose immediately transforms your formula from a standard mix into a "stabilized" premium product with guaranteed longer shelf life.
Q2 Does Trehalose affect the compression force needed for tableting?
Trehalose exhibits excellent binding properties and compressibility. It performs similarly to direct-compression sugars, meaning you do not need to alter your standard tableting parameters, while still gaining the benefit of bacterial cell protection.
Q3 Is it suitable for diabetic-friendly supplement formulations?
Trehalose is a fully digestible carbohydrate. While it elicits a lower insulin response compared to glucose, it still contains calories (4 kcal/g). For strictly zero-calorie or keto-friendly supplements, we recommend blending it with Erythritol or our high-intensity sweeteners.
Q4 What is the shelf life and correct storage condition of this Trehalose?
Our high purity Trehalose has a shelf life of 24 months. It should be stored in a cool, dry environment, strictly protected from moisture, humidity, and strong external odors to maintain its low hygroscopic qualities.
Q5 What global certifications and regulatory compliances does the product have?
It is fully GRAS (Generally Recognized As Safe) certified and conforms to international Dietary Supplement and Nutraceutical regulations. Production occurs under strictly audited ISO 22000 and HACCP conditions, additionally granting it 100% Halal and Kosher status.
Q6 How does Trehalose actively increase gastric survival rates of probiotics?
It physically structures a protective buffer layer around the bacteria's membrane, enabling it to withstand the aggressive, highly acidic environments inside the stomach, thereby boosting the total viable CFU counts that successfully populate the digestive tract.

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